The dry extract of different parts of the Derris elliptica is used in fish ponds to harvest and control predatory fish.However, the toxicological impact of the extract on fish has not yet been evaluated. The objective of the present study is toinvestigate the effects of the extract on some enzymes of plasma of the widely consumed African catfish Clariasgariepinus. Fish specimen were exposed to sublethal concentrations (0.00 [control], 0.75, 1.50 and 3.00g/L) of dry extractof stems of D. elliptica for 24, 72 and 168 h adopting the semi-static renewal bioassay technique and were then subjectedto plasma analyses. The level of plasma acid phosphatase and plasma alkaline phosphatase decreased significantly(P<0.05) while plasma alanine aminotransferase and plasma aspartate aminotransferase increased significantly (P<0.05). Itwas concluded that the dry extract of the stem of D. elliptica produced disorders in liver, kidney and respiratorymetabolism of C. gariepinus.