This study is aimed at finding out the effect of Moringa oleifera on blood parameters and body weights of albino rats (n=24) and rabbits (n= 10). The rats were divided into four groups; a control group and three experimental groups, while therabbits were divided into two groups; a control group and an experimental one. The three experimental groups of rats wereprovided consecutively with100, 200 and 300 mg M. oleifera leave extract/kg of body weight daily for 21 days, while theexperimental group of rabbits with 2.5 g fresh leaves of M. oleifera/Kg of body weight which was added to their feed dailyfor 21 days, and the control groups were fed on their diets without M. oleifera. The results showed significant differences (P< 0.05) in mean cell hemoglobin concentration (MCHC) and platelets (PLT) in the third group of rats (AL3) and red bloodcells (RBCs) count, hemoglobin (Hb) and MCHC in the fourth group (AL4) while no significant differences (P > 0.05) wereshown in the second group (AL2). For the rabbits, the mean values of 39.30 ± 1.73, 741.80 ± 65.5 and 5.06 ± 0.54 for PCV,PLT and RBCs in the experimental group were significantly higher (P < 0.05) than 33.12 ± 4.32, 344.20 ± 66.6 and 4.68 ±0.81 for the same parameters in the control group, respectively.