Objective: This work aims to evaluation of IL-12 as a biomarker in hepatic patients, chronically infected patients, hepatic patients Under treatment, recovered patients and vaccinated patients. Methodology: The liver function pattern of these groups were monitored using biochemical assays relative to IL-12 as a biomarker using ELISA. Results: Data Recorded revealed that there was a highly significant negative correlation between Interleukin-12 and ALT level, Total Bilirubin and Total Bilirubin (P<0.05). In the mean time, there was a highly significant negative correlation between Interleukin-12 and AST level, Albumin and Alkaline phosphatase. Conclusion: IL-12 can be used as a biomarker for the hepatic infection