Background: suboptimal knowledge on medication practices, safety, and negative attitudes has some negative impact concerning managing different types of diseases.Objectives: the primary objective of this research work was to measure the public knowledge and to identify their attitudes and practices on medication practices, with mainly focus on colorectal cancer and diabetes. This is because they are ranked as the major diseases in the Kingdom of Saudi Arabia, accounting for about 10.4% according to recent researchesSubjects and methods: the study was based on two cross-sectional surveys focusing on public support and the internet based research.Results: women constituted 55% of the cohort (n=420). The age of the participants ranged between 18 and 74 with the mean of 37 years. About a quarter of the respondents correctly identified colonoscopy and FOBT as primary screening tools. Seventy percent of the respondents agreed with the statement that there are misconceptions about the contraction of cancer and diabetes. Nearly forty participants reported that they never combined traditional medicine in treating the epidemics with about 30 of them had a failure to ask the community doctors on the need to be checked on the possibility of the having the disease.Conclusion: majority of the adult had adequate knowledge and attitudes scores, but they were not adhering to health promotion activities. Furthermore, misconceptions in knowledge, attitudes, and practices on medication use were prevalent.