This study was designed to determine the levels of two toxic elements (lead and cadmium) in kidney, liver and the muscles of camels and sheep. The samples of slaughtered animals were collected from different western regions (Zawia, Sorman and Egilate) in Libya. The Atomic Absorption spectrophoto-meter was used to carry out the measurements of heavy metals of samples. A recognized highly significant effects (P≤ 0.01) of species; Parts of body, region and interaction among them on residual of lead and cadmium in kidney, liver and muscle were measured. The concentration of lead and cadmium were 107.42 and 53.0 μg/kg in camels, which higher than values measured for sheep (75.32 and 17 μg/kg). The concentration of lead and cadmium were 143.33 and 50 μg/kg; 93.66 and 45 μg/kg and 53.16 and 28 μg/kg in kidney, liver and muscle, respectively. Regarding the effect of region, the concentration of lead and cadmium were 118.62 and 48 μg/kg; 81.25 and 41μg/kg and 90.29 and 34 μg/kg for Zawia, Sorman and Egilate regions, respectively. The reference values of lead and cadmium concentration in kidney and liver reported by Egyptian Organization for Standardization (EOS) and FAO are 0.5 mg/kg (500μg/kg) and 0.1 mg/kg (100μg/kg), respectively. Thus, the mean concentrations of lead and cadmium in kidney, liver and muscle of slaughtered camels and sheep in this study were safe and lower than permissible limit recommended. Information about levels of these metals is very important to the consumers because they are awareness concern with healthy food especially meat.