Hypomineralization of Incisors and Molars, known as MIH, is an enamel qualitative defect of systemic origin. Although studies were carried out in various countries, none of them was reported on the Lebanese population. The purpose of this preliminary clinical observation is to increase awareness of this disease within Lebanese and Arab dental communities, and to encourage dentists towards its early diagnosis and contemporary treatments (such as amelioration of oral hygiene, re-mineralization with fluoride, application of calcium and bio-available phosphate, and fissure sealant up to partial or total coverage in case of severe damage of tooth hard tissue).