The cardiovascular effects of lead (Pb) are not only limited to increased blood pressure and hypertension, but they are also associated with an increased incidence of coronary heart disease, stroke, and peripheral arterial disease. The present study evaluates the effects of Pb poisoning in 90 Albino rats and its amelioration using different concentrations of mushroom/growers mash feed mixture. The results of the present work showed that mushrooms (Pleurotus tuberregium) were able to ameliorate the effect of lead toxicity by reducing total cholesterol, Low Density Lipoprotein/High Density Lipoprotein-cholesterol (LDL/HDL-ch) and Coronary Risk Index (CRI) (except in the group of rats fed with 90% feed+ 10% P. tuberregium) and to increase HDL-ch in the experimental rats (except in the group of rats fed with 90% feed+ 10% P. tuberregium) when compared to the control.