Objectives: To ascertain the association between co-residence and the prevalence of self-reported depressive symptoms among Kuwaiti men and women aged 50+. Methods: A cross-sectional survey of Kuwaiti households was conducted among 2,487 persons aged 50+. A scale containing 10 items (each ranging from 0-3) was used to calculate the depressive symptom score. Binary logistic regression was used to identify predictors of ? median level of the depressive symptoms score. Results: The mean depressive symptoms score was 10.97. Women had a significantly higher mean score than men. Those with no co-resident children were 2.2 times more likely to report higher depressive symptoms than those with 3+ children. Those with three illnesses were more likely (3.6 times among men and 2.1 times among women) to report higher depressive symptoms than their counterparts without any illness. Discussion: Co-habitation with a larger number of children was inversely associated with depressive symptoms experience.