Background: Herbal medicine can be called one of the branches of medicine in various forms. Turmericcurcuminhas proved its efficiencies a coloring, flavoring agent and has been traditionally used in medicine, exhibitingremarkable anti-inflammatory and antioxidant properties. The varied biological properties of curcumin and lack oftoxicity even when administered at higher doses makes it attractive to explore its use in various disorders like diseasesof skin. It is good potential agent for wound healing.Materials and methods: Sixty four new Zealand rabbits were used in this study ,they were divided into fourgroups,each group was subdivided as follows: Experimental groups(8 rabbits) right facial side of animals for essentialoil application and left facial side animals for curcumin powder application, 8 animals as control group(right facialsides) .Histological assessment regarding the count of inflammatory cells was performedon all studied samples for thehealing intervals (3, 7, 10, and14 days).Results: Histological findings of the study showed that re-epithelialization, wound contraction were accelerated aftertopical application of curcumin material especially the essential oil at wound site.Conclusion: Topical application of curcumin essential oil was significantly effective in skin wound healing ascompared to curcumin powder.