Quality of life (QOL) research has been identified as a priority for nursing. A wide variety of QOL instruments have been developed to address a number of domains such as physical, functional, emotional, and social well-being (Corner & Baliey, 2008, & Stewart). It has been proposed that meaning should also be included, as well as purpose, spirituality and grief (Sepúlveda, Marlin, Yoshida, & Ullrich, 2002). Evaluation of QOL instruments in palliative care is an important research priority. Considerable research has addressed the QOL and quality of care aspects for palliative patients, but there has been limited evaluation of the measurement technique for both in the Middle East. To the authors’ knowledge no studies have been conducted to explore this issue in the Middle East, and certainly not in Qatar. Therefore, this project promises to develop a new insight into the importance of evaluating the QOL measurement instruments that could potentially be used in the palliative care unit in Qatar. The overall objective of this paper was to examine the findings of an integrative literature review for the purpose of determining cultural adaptations and validations of instruments needed to evaluate the QOL of patients in palliative care, and to discuss the use of these instruments in the Middle East context.