The nematodes Wuchereria bancrofti and Brugia malayi; the principal etiologicagents of lymphatic filariasis are mosquito dependant in the biologicaltransmission. Dirofilariasis is essentially a disease of canines which can also betransmitted to humans by culicine mosquitoes.The present work studied the histological and PCR xenomonitoring filarialinfestation in culicine mosquitoes in Sohag Governorate. One hundred femalemosquitoes of the 5 culicine spesies present in the selected localities, weredissected and histological sections of thoracic muscles were examined for filariallarvae. Also 50 female Culex pipiens molestus were collected from the same areasand tested for 3 filarial worms using PCR. Cx. pipiens molestus was the onlyculcine mosquito harbouring larvae of Wuchereria bancrofti and Dirofilaria spp.Results were compared and it was found that PCR proved easier to do and it gavebetter data as it was able to differentiate dirofilarial species. The results indicateda clear success of health authorities in anti-filariasis control measures and pointedout to avoid the hazard of possible occurrence of future cases of humandirofilariasis in Sohag Governorate.