This paper analyzed the economic impact of media campaign against HighlyPandemic Avian Influenza (HPAI), popularly called bird flu, on poultrybusiness in Ogun state. Eighty four farmers were randomly sampled from thefour poultry zones identified by the state’s veterinary department. Descriptivestatistics and the Gross Margin analysis were used to analyze the datacollected. The Results showed that average market price of all poultry birds andeggs dropped by more than 50% except for day old broilers and day old pulletswhich dropped by 41% and 42% respectively. The fall in price was adduced tothe reported outbreak of HPAI. The paper recommended that strict policyguiding the reporting of infections, campaign regarding the pandemic shouldemploy collaborative effort of professionals such as communicators,information scientists, veterenary doctors etc especially in the rural areas