Background: Quality of life (QoL) has become a major outcome in the treatment of patients with cancer. This study is aimed at examining the impact of chemotherapy-induced nausea and vomiting on QoL of patients among cancer patients. Methodology: A systematic search of the literature published between 2006 and 2012 was undertaken to identify research available on chemotherapy induced nausea and vomiting and quality of life. The mixed methods review was conducted using critique quantitative studies prospective. Result: It is commonly claimed that the nausea and vomiting accompanying cytotoxic chemotherapy have a negative impact on quality of life. While this may seem self-evident, there is little empirical data demonstrating that the failure to control chemotherapy nausea and vomiting affects aspects of quality of life other than directly related physical symptoms. Conclusion: Even if the number of the published studies specifically aiming to evaluate the impact of chemotherapy-induced nausea and vomiting (CINV) on Quality of life (QL) can be considered high, those showing results that are reliable and helpful to orient the clinical decision are few. Also considering the improvement in antiemetic therapy obtained in the last few years, and the more frequent implementation of reliable antiemetic guidelines, as well as the recent increasing diffusion of lower emetogenic chemotherapies, more research should be performed to obtain results on the impact of CINV on QL useful to orient the choice of antiemetic therapy.