Background: Pressure ulcer is a major complicated clinical problem caused by multi- factorial etiology. It is associated with many risk factors that are quite similar to the signs and symptoms of oncological disorders. Pressure ulcer can impact patients’ quality of life in many aspects. A patient might die from pressure ulcer rather than cancer itself. Significance: Preventing pressure ulcers from occurrence might bring a great positive impact on the whole health care system in many aspects, including socially and economically. Purpose: The purpose of this review is to collect the best evidence on pressure ulcers in order to assist nurses in being able to define, assess, stage and prevent their occurrence. Methods: Relevant research concerning pressure ulcer assessment and prevention in oncology patients was identified by searching the medical and nursing sciences databases for primary research material. Results: There is general consensus on definition and staging of pressure ulcers in different settings and locations, while assessment and prevention remain open for further research and studies based on available resources, training and patients’ characteristics. Conclusion: Developing a program or protocol for early assessment and prevention of pressure ulcer has a major impact in reducing its incidence and improving the outcome of oncology patients.